Evidence-based guide to weight loss peptides: Semaglutide, Tirzepatide & GLP-1 agonists
Get Started →FDA-approved GLP-1 receptor agonists with proven clinical results
Mounjaro® (diabetes) | Zepbound® (weight loss)
FDA APPROVEDThe most effective weight loss medication available. Dual GIP/GLP-1 receptor agonist approved in 2022-2023.
Ozempic® (diabetes) | Wegovy® (weight loss)
FDA APPROVEDThe gold standard GLP-1 agonist. Extensively studied with proven cardiovascular benefits.
Victoza® (diabetes) | Saxenda® (weight loss)
FDA APPROVEDFirst-generation GLP-1 agonist. Daily injection with established safety profile.
How do the top weight loss peptides compare?
| Peptide | Weight Loss | Dosing Frequency | FDA Approval | Monthly Cost |
|---|---|---|---|---|
| Tirzepatide | 20-22% | Weekly | ✓ 2022-2023 | $1,000-1,400 |
| Semaglutide | 15-17% | Weekly | ✓ 2021 | $900-1,400 |
| Liraglutide | 8-10% | Daily | ✓ 2014 | $1,300-1,500 |
Tirzepatide offers the highest weight loss but is newer with less long-term data. Semaglutide has the most extensive research and proven cardiovascular benefits. Liraglutide is the most established but requires daily injections and produces less weight loss.
Understanding the mechanism behind 15-22% weight loss
GLP-1 agonists activate receptors in the brain that control hunger and satiety. You feel full faster and stay satisfied longer between meals.
Result: 20-30% reduction in caloric intake without conscious effort.
These peptides slow how quickly food leaves your stomach, extending the feeling of fullness after eating.
Result: Reduced portion sizes and fewer cravings throughout the day.
GLP-1 agonists improve insulin sensitivity and reduce glucose production in the liver, stabilizing blood sugar levels.
Result: Fewer energy crashes and reduced carbohydrate cravings.
GLP-1 agonists are prescription medications that require medical supervision. Common side effects include nausea, vomiting, diarrhea, and constipation, especially during dose escalation. Serious risks include pancreatitis, gallbladder disease, and thyroid tumors (in animal studies).
These medications are not suitable for everyone. Contraindications include personal or family history of medullary thyroid cancer, multiple endocrine neoplasia syndrome type 2, and severe gastrointestinal disease.
Your roadmap to safe and effective weight loss
Schedule an appointment with a healthcare provider experienced in weight management. They'll assess your eligibility, review your medical history, and determine the best peptide for your situation.
Required: BMI ≥30 or BMI ≥27 with weight-related conditions.
Your provider will prescribe the appropriate peptide and starting dose. All GLP-1 agonists require gradual dose escalation over 16-20 weeks to minimize side effects.
Use our calculator: Calculate your dosing schedule →
While peptides dramatically reduce appetite, combining them with healthy eating and regular exercise maximizes results and helps maintain weight loss long-term.
Expected timeline: 68 weeks average treatment duration.